Description

SCIENTIST – CellBiology

Angiex, Inc. –LabCentral, Cambridge, MA 02139

Angiexis an innovative science-focused startup developing vascular-targeted biologictherapies for cancer and other diseases. Angiex’s lead program is anantibody-drug conjugate therapy for solid cancers. Angiex was launched out ofBeth Israel Deaconess Medical Center and Harvard Medical School in 2016, isresident at LabCentral in Cambridge, and is backed by prestigious investors.Angiex founders have previously discovered VEGF-A, been recognized as theworld’s leading experts in tumor blood vessel biology, developed new methodsfor per cell mRNA quantification, founded four companies, written abest-selling diet book, and won prizes for best salsa and pie recipes atLabCentral.

Job Description:

Angiex is seeking a talented, creative, self-motivated cellbiologist to join in the investigation of novel cellular pathways inendothelial cells and tumor cells and the discovery and design of drugsspecific to those pathways. The successful candidate will haveextensive hands-on experience in cell biology, cell signaling assays, cellculture, imaging, and intracellular trafficking, and ability to perform in vivo mouse studies. Immunology orimmuno-oncology expertise, or experience studying endothelial-leukocyteinteractions, is a plus. The job offers exceptional opportunity for careerdevelopment in one of Boston’s most exciting and promising biotech startups.

Responsibilities:

• Develop and implement biochemical approaches and technologies to establish the activity, mechanism of action, trafficking, and metabolism of candidate therapeutics both in cells in vitro and mice in vivo.
• Perform imagingstudies using confocal microscopy, superresolutionimaging, and electron microscopy.
• Characterize the potency and signaling activity of candidate therapeutics in vitro and support selection of candidates for in vivo efficacy studies.
• Develop and implement assays to evaluate molecular interaction networks in vitro and tissue specific cell signaling of candidate antibodies in vivo.
• Cure cancer.

Requirements:

• Ph.D. in biology,biochemistry, immunology, or a related discipline with substantial experiencein wet-bench laboratory work and a strong record of accomplishment including astrong publication record.
  
• Experience in cellbiology, especially in intracellular trafficking, microtubule biology, geneexpression regulation, cell cycle, andapoptosis.
• Highly self-motivated,talented, and versatile candidate who can excel in a fast-paced and cooperative working environment, and who works with independent initiative yet in a team-oriented manner.
• Capable of building strong, intimate, cooperative relationships with peers within the firm and partners outside the firm, relationships characterized by honesty, transparency, humility, and integrity.
• Excellent oral and written communication skills.
• Be talented enough to rapidly master tasks you've never done before, cooperative and communicative enough to make a great team even stronger, dedicated enough to accomplish in one week what others do in two, careful enough that experimental results are reliable, honest enough to say when they aren't, creative enough to wake up at 3 AM with ideas you can't wait to share, and cheerful enough to enjoy to the fullest the most exciting job you'll ever have.
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Benefits: Angiexprovides a highly competitive package of benefits including a broad selectionof medical, dental, and vision plans, 401k plan, free parking in an adjacent garage or afree MBTA pass, and free membership at MIT Recreation.

Statement: Angiex is an equalemployment opportunity employer and does not discriminate against any applicantbecause of race, creed, color, age, national origin, ancestry, religion,gender, sexual orientation, disability, genetic information, veteran status,military status, application for military service or any other class protectedby state or federal law.