Description

Engitix Therapeutics is a pioneering biotech company dedicated to unlocking extracellular matrix biology to develop transformative therapeutics in fibrosis and oncology. We are seeking an accomplished Senior Scientist of Macrophage Biology to play a leading role in defining novel targets in the macrophage-stromal interface.

We are looking for an expert in macrophage biology, who will use their experience to establish a high throughput monocyte and macrophage supply chain for biology and drug screening groups across the Discovery unit. In addition, you will be a lead in the nomination and validation of new targets at the macrophage-stromal interface with the potential to deliver therapeutic impact in both oncology and fibrosis disease areas.

You will also be a key member of a team establishing macrophage-based target screening assays combined with our novel extracellular matrix-based cell models and will utilise cellular, immunological, biochemical, molecular biology and functional genomic approaches to validate drug targets and novel therapeutic agents.

• Establish high throughput supply of monocyte derived macrophages for multiple groups across the Engitix organisation
• Drive novel macrophage drug target nomination and validation
• Optimise co-culture assay systems based on stromal-macrophage interface in 2D and 3D platforms for drug screening
• Optimise macrophage target screening-based systems utilising functional genomic approaches such as siRNA and CrispR.
• Analyse, interpret, report and present results

Key Experience:

• Demonstrable expertise in macrophage biology, in particular phagocytosis pathways
• Demonstrable experience in immuno-oncology and/or fibrosis research
• Expertise in the use of multi-colour flow cytometry and IF techniques on tissue sections
• Hands-on experience of key immunological and molecular biology techniques including MSD, RNA/DNA extraction, qRT-PCR, western blotting, siRNA knockdown

• Familiarity with molecular pharmacology and oncology drug development
• Prior laboratory research experience in the biotech/pharma industry

• PhD in Biomedical Sciences, Immunology, Biochemistry, Biotechnology, or a related discipline, plus 3 years’ experience in a drug screening environment; or an MSc plus 6 years of practical experience with a focus on immuno-oncology or fibrosis
• Ability to plan, execute, and critically assess experiments independently
• Excellent time-management skills and ability to work to set deadlines
• Excellent written and verbal communication skills and the ability to work effectively within a team
• Strong troubleshooting skills, with a methodical approach, high attention to detail, and the ability to maintain accurate records

• Be part of a pioneering biotech transforming drug discovery through ECM biology
• Work in a collaborative, fast-paced environment with opportunities to shape the future of targeted therapeutics
• We offer a competitive package including private medical insurance, pension, bonus, employee perks and more

Engitix is a growing biotech company based in White City Place, West London. We are dedicated to developing better therapies for advanced fibrosis and solid tumours by leveraging our pioneering extracellular matrix (ECM) platform. Our platform allows the synthesis of realistic in vitro 3D models that serve as tools to transform our ability to identify new targets and biomarkers, determine mechanisms of action and more accurately predict the efficacy of therapeutic candidates.

Join us today in our mission to create a healthier future for patients with life-threatening diseases such as fibrosis and cancer.